Related Experiment Videos
Hemolysis with rapid transfusion systems in the trauma setting
Peter Kim1, Ian Chin-Yee, Kathleen Eckert
1Faculty of Medicine, University of Western Ontario, London Health Sciences Centre, London, Ont.
Canadian Journal of Surgery. Journal Canadien De Chirurgie
|September 15, 2004
Summary
The Level 1 Rapid Infuser safely transfused 17 units of packed red blood cells in trauma patients, showing minimal hemolysis. This rapid infusion system is effective for massive transfusions, with no clinically significant red blood cell damage observed.
Area of Science:
- Transfusion Medicine
- Trauma Care
- Hematology
Background:
- Rapid infusion systems are crucial for delivering resuscitation fluids at body temperature to trauma patients.
- Packed red blood cells are often infused under high pneumatic pressure and through filters, raising concerns about potential hemolysis.
Purpose of the Study:
- To evaluate the extent of hemolysis in packed red blood cells when subjected to rapid infusion using the Level 1 Rapid Infuser during massive transfusion protocols (> 10 units).
Main Methods:
- Infused 17 units of outdated packed red blood cells using the Level 1 Rapid Infuser.
- Measured pre- and post-transfusion levels of lactate dehydrogenase (LDH), potassium, plasma hemoglobin, hematocrit, and total hemoglobin.
- Calculated hemolysis percentage based on measured parameters.
Main Results:
- Observed hemolysis ranged from 0% to 0.05%, indicating minimal red blood cell damage.
- All transfused units exhibited plasma potassium concentrations of 15 mmol/L or higher.
Conclusions:
- The Level 1 Rapid Infuser did not cause clinically significant hemolysis when transfusing 17 units of packed red blood cells.
- The system appears safe for use in massive transfusion scenarios in trauma patients.