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Updated: Jul 30, 2026
22:06
Induction and Monitoring of Adoptive Delayed-Type Hypersensitivity in Rats
Published on: October 1, 2007
[Tolerance induction towards nickel. From animal model to humans]
S Artik1, E Gleichmann, T Ruzicka
1Institut für umweltmedizinische Forschung an der Heinrich-Heine-Universität Düsseldorf gGmbH, Abteilung für Allergologie und Immunologie, Universitätshautklinik, Heinrich-Heine-Universität Düsseldorf artik@uni-duesseldorf.de
Summary
Nickel allergy is common, and understanding tolerance is key. This review explores mechanisms and oral tolerance induction in mouse models and humans for better prevention and therapy.
Area of Science:
- Immunology
- Dermatology
- Toxicology
Context:
- Nickel is the most frequent contact allergen globally.
- Mechanisms of nickel allergy and tolerance have remained incompletely understood.
- Advancements in animal models aid in studying these immunological responses.
Purpose:
- To review current research on nickel allergy and tolerance mechanisms.
- To explore the potential of oral tolerance induction for nickel allergy.
- To provide perspectives on future prevention and therapy strategies.
Summary:
- This review synthesizes findings on nickel allergy pathogenesis and tolerance mechanisms.
- It highlights the utility of a reproducible mouse model alongside human studies.
- The article discusses the potential of oral tolerance induction in both animal models and humans.
Impact:
- Enhanced understanding of nickel allergy pathogenesis.
- Provides a basis for developing targeted prevention and therapy for nickel allergy.
- Offers insights into novel approaches like oral tolerance induction.
