Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modeling mitochondrial function in aging neurons.

Simon Melov1

  • 1Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. smelov@buckinstitute.org <smelov@buckinstitute.org>

Trends in Neurosciences
|September 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-nucleus profiling reveals age-associated remodeling opposed by parity in the postmenopausal human ovary.

bioRxiv : the preprint server for biology·2026
Same author

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons.

Aging cell·2026
Same author

Senescent Schwann cells as therapeutic targets in nerve regeneration and peripheral neuropathies.

Trends in molecular medicine·2026
Same author

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics.

Research square·2026
Same author

CD38 Inhibition Ameliorates Age-Related CognitiveDecline via a Choroid Plexus-Cerebrospinal Fluid-Hippocampus Axis.

Research square·2026
Same author

Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial Transcriptomics.

bioRxiv : the preprint server for biology·2025
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
Same journal

The neural basis of laughter.

Trends in neurosciences·2026
Same journal

Enteric neuroimmune interactions in health and disease.

Trends in neurosciences·2026
Same journal

Atomic insights into the physiological and functional diversity of NMDA receptors.

Trends in neurosciences·2026
Same journal

Cognitive functions of the GPe.

Trends in neurosciences·2026
See all related articles

Mitochondria play a key role in aging. New animal models reveal how mitochondrial dysfunction contributes to aging-related diseases, offering insights into cellular aging processes.

Area of Science:

  • Cellular Biology
  • Mitochondrial Biology
  • Aging Research

Background:

  • Mitochondria are central to cellular functions including energy production, biosynthesis, and apoptosis.
  • Mitochondria are the primary source of reactive oxygen species (ROS) in cells.
  • Mitochondrial dysfunction is increasingly implicated in the aging process.

Purpose of the Study:

  • To review recent advancements in animal models of mitochondrial dysfunction.
  • To explore the connection between mitochondrial pathophysiology and aging.

Main Methods:

  • Review of current scientific literature.
  • Analysis of new animal models exhibiting mitochondrial dysfunction.
  • Focus on mitochondria-mediated aging processes.

Related Experiment Videos

Main Results:

  • Emerging animal models provide significant insights into aging-related mitochondrial pathophysiology.
  • These models highlight the complex role of mitochondria in cellular aging.

Conclusions:

  • Mitochondria are intrinsically linked to aging.
  • New animal models are crucial for understanding mitochondria-mediated aging and developing interventions.