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Updated: Aug 22, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Cushing's disease treatment with transsphenoidal surgery during pregnancy]
Cecilia Verdugo1, Jorge Alegría, Carlos Grant
1Sección Endocrinología, Servicio de Medicina Interna, Hospital Regional Guillermo Grant B, de Concepción, Universidad de Concepción, Chile. cverdugo@udec.cl
Abstract:
We report a 26 year old female with Cushing's disease who became pregnant during the course of her disease. She was treated by transsphenoidal surgery during the second trimester of pregnancy, achieving resolution of hypercortisolism. She had a normal delivery at term, her offspring was healthy, and she had a normal lactation. Currently, five years after surgery, she is asymptomatic. According to our literature review, this patient is the fifth reported case of pituitary adenomectomy during gestation.
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