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Acidic mammalian chitinase--a potential target for asthma therapy
Louise E Donnelly1, Peter J Barnes
1Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK.
Trends in Pharmacological Sciences
|September 24, 2004
Summary
Inhibiting acidic mammalian chitinase showed significant anti-inflammatory effects in an asthma model. This suggests chitinase is a potential therapeutic target for allergic diseases like asthma.
Area of Science:
- Biochemistry
- Immunology
- Allergy Research
Background:
- Acidic mammalian chitinase inhibition demonstrated anti-inflammatory effects in a murine asthma model.
- This finding suggests chitinase as a potential therapeutic target for T helper 2-driven diseases.
Purpose of the Study:
- To investigate the role of acidic mammalian chitinase in asthma pathology.
- To explore the mechanism of action for chitinase in mediating allergic inflammation.
Main Methods:
- Utilized a murine model of asthma.
- Investigated interleukin 13-dependent and STAT6-independent pathways.
Main Results:
- Inhibition of acidic mammalian chitinase yielded profound anti-inflammatory effects.
- The enzyme mediates interleukin 13-dependent responses independently of STAT6.
Conclusions:
- Acidic mammalian chitinase is implicated in asthma pathogenesis.
- Chitinase family members may be key mediators in allergic diseases, including asthma.