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Collaborative iIslet Transplant Registry.

N C Close1, B J Hering, R Anand

  • 1The EMMES Corporation, Rockville, Maryland, USA.

Clinical Transplants
|September 25, 2004
PubMed
Summary
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The Collaborative Islet Transplant Registry (CITR) collects North American islet transplant data. This registry aims to analyze islet transplantation outcomes to improve patient care for diabetes.

Area of Science:

  • Transplantation immunology
  • Endocrinology
  • Clinical research

Background:

  • The Collaborative Islet Transplant Registry (CITR) was established in 2001 to gather and analyze islet transplant data in North America.
  • Supported by the National Institute of Diabetes and Digestive Diseases, CITR aims to centralize information from participating islet transplant centers.

Purpose of the Study:

  • To describe the organization, goals, and data collection instruments of the Collaborative Islet Transplant Registry (CITR).
  • To establish a framework for collecting and analyzing comprehensive data on islet transplantation procedures and outcomes.

Main Methods:

  • CITR was established in 2001, with 13 centers participating by January 2004, collecting data on 58 recipients and 107 islet transplants.
  • Data collection includes recipient demographics, diabetes history, donor characteristics, and islet infusion parameters.

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  • The registry utilizes standardized data collection instruments to ensure consistency across participating centers.
  • Main Results:

    • Preliminary data from October 2003 included 58 recipients (average age 41, diabetes duration ~28 years, 67% female) and 118 deceased donors.
    • Islet infusion averaged 7,127 islets/kg recipient weight.
    • Procurement and infusion data were collected, with outcome data pending the first annual report.

    Conclusions:

    • The Collaborative Islet Transplant Registry (CITR) provides a structured approach to collecting critical data on islet transplantation.
    • The registry's design facilitates the analysis of islet transplant procedures and patient outcomes.
    • CITR is poised to contribute valuable insights into optimizing islet transplant therapies for type 1 diabetes.