Quadrupole ion trap studies of fundamental organic reactions

Scott Gronert1

  • 1Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, USA. sgronert@sfsu.edu

Mass Spectrometry Reviews
|September 25, 2004
PubMed

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Here, in contrast to the E2 reaction mechanism, we delve into the aspects of the E1 reaction mechanism, which has two steps: rate-limiting loss of the leaving group and abstraction of the beta hydrogen by a weak base. Typically, the experimental proof for the E1 mechanism is via kinetic studies or isotope studies. While the former demonstrates the first-order kinetics—the dependence of the reaction solely on substrate concentration—the latter proves the abstraction of hydrogen only in the...
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Elimination reactions of alkyl halides can yield one or more alkenes depending on the specific regiochemical and stereochemical considerations. While the regiochemistry of the reaction governs the location of the double bond in the product, the stereochemical requirements often influence the geometry.
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