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Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy
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Invasive Aspergillus niger with fatal pulmonary oxalosis in chronic obstructive pulmonary disease

E A Kimmerling1, J A Fedrick, M F Tenholder

  • 1Medical College of Georgia, Augusta.

Chest
|March 1, 1992
PubMed

Insights

Aspergillus fungus causes various lung diseases. Black debris, fungus balls, or acidic sputum may indicate Aspergillus niger infection and its oxalic acid byproduct.

Area of Science:

  • Mycology
  • Pulmonology
  • Infectious Diseases

Background:

  • The ubiquitous Aspergillus fungus presents diverse clinical manifestations in lung disease, including primary pneumonia, aspergilloma, allergic bronchopulmonary aspergillosis, and invasive forms.
  • Aspergillus can initially colonize existing lung conditions indolently before becoming acutely invasive.

Observation:

  • Aspergillus niger, though less common, is suggested by specific visual and chemical findings.
  • Endobronchial observation of black necrotic debris or a fungus ball is a key indicator.
  • The presence of black, acidic sputum or pleural fluid further suggests Aspergillus niger.

Findings:

  • Aspergillus niger produces oxalic acid as a destructive fermentation byproduct.
  • These characteristic findings aid in diagnosing Aspergillus niger infections.

Implications:

  • Early identification of Aspergillus niger is crucial for timely and effective treatment.
  • Understanding the role of oxalic acid may lead to targeted therapeutic strategies.
  • Recognizing these specific signs can improve patient outcomes in Aspergillus-related lung diseases.

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