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Case report: solid-phase platelet crossmatching to support the alloimmunized patient
1University of Maryland Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA.
Immunohematology
|January 1, 1995
Summary
Platelet crossmatching using a solid-phase red cell adherence assay identified compatible platelets for alloimmunized leukemia patients. This method successfully improved platelet counts, supporting its use for refractory thrombocytopenic patients.
Area of Science:
- Hematology
- Immunology
- Transfusion Medicine
Background:
- Alloimmunized patients with leukemia often experience refractoriness to platelet transfusions.
- Identifying compatible platelet donors is crucial for managing thrombocytopenia in these patients.
Purpose of the Study:
- To evaluate the efficacy of solid-phase red cell adherence assay for platelet crossmatching.
- To determine the success rate of transfusions with crossmatched platelets in alloimmunized leukemia patients.
Main Methods:
- Solid-phase red cell adherence assay was employed for platelet crossmatching.
- Corrected count increment (CCI) >7,500 defined a successful platelet transfusion.
- Random platelet concentrates and apheresis donations were crossmatched and transfused.
Main Results:
- For Patient A, 4 out of 5 transfusions with crossmatched platelets were successful (CCI >7,500).
- For Patient B, 71 out of 78 transfusions with crossmatched platelets were successful (CCI >7,500).
- Platelet crossmatching identified suitable apheresis donors, significantly improving transfusion success rates.
Conclusions:
- Solid-phase red cell adherence assay is effective for platelet crossmatching in alloimmunized patients.
- Platelet crossmatching is a valuable strategy for supporting refractory thrombocytopenic patients.
- This approach enhances transfusion efficacy and donor identification for specialized needs.