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Updated: Aug 21, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Preclinical study of the effect of cardiotropic agents on isolated heart
D V Gol'dshtein1, A A Zakaryan, V S Kuz'min
1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
Abstract:
Direct effects of cardiotropic preparations on the hearts isolated from Wistar rats were examined. Deenergization of cardiomyocytes was modeled under conditions of hypoxic perfusion. Recovery of cardiac function during reperfusion was assessed by changes in the heart rate and contraction amplitude.
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