Related Experiment Video
Updated: Aug 21, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
Published on: February 3, 2021
Stimulation of vagus nerve modifies negative chronotropic and hypotensive effects of adenosine
N I Ziyatdinova1, A A Gainullin, A U Ziganshin
1Department of Anatomy, Physiology, and Human Health Protection, Kazan State Pedagogical University.
Abstract:
The effects of electrical stimulation of the vagus nerve on the negative chronotropic and hypotensive effects of adenosine were studied on adult rats. Intravenous injection of adenosine to control rats significantly reduced the heart rate and induced a transient blood pressure drop followed its increase. Preliminary electrical stimulation of the right vagus nerve reduced the magnitude and duration of adenosine-induced bradycardia and changed the dynamics of adenosine-induced arterial pressure perturbations.
Related Concept Videos
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Adrenergic Agonists: Direct-Acting Agents
These agents can be classified...
Heart Failure Drugs: Inotropic Agents
Drugs Affecting Neurotransmitter Release or Uptake

