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Updated: Jan 13, 2026

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
Effect of α2-Adrenergic Receptors Stimulation after If Blockade on the Heart of Rats with Acute Myocardial Infarction
A M Kuptsova1, N I Ziyatdinova1, L I Faskhutdinov1
1Kazan (Volga Region) Federal University, Kazan, Russia.
Abstract:
We studied the effect of α2-adrenergic receptors stimulation against the background of If blockade on the function Langendorff-isolated rat heart during the acute stage of myocardial infarction. Stimulation of α2-adrenergic receptors against the background of ZD7288 blocker (10-9, 10-5 M) decreased HR, increased the left-ventricular developed pressure and the temporal and velocity characteristics of left-ventricular myocardial contraction, produced a multidirectional effects on coronary flow and duration of left-ventricular myocardial contraction in rats with acute myocardial infarction.
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