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Endoscopically compatible near-infrared photon migration probe.

Carmalyn Lubawy1, Nirmala Ramanujam

  • 1Department of Biomedical Engineering, University of Wisconsin--Madison, Madison, Wisconsin 53706, USA.

Optics Letters
|October 1, 2004
PubMed
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A new fiber-optic probe enables near-infrared spectroscopy during breast biopsies. This tool accurately measures optical properties of simulated lesions, aiding in cancer detection.

Area of Science:

  • Biomedical Optics
  • Medical Imaging
  • Cancer Diagnostics

Background:

  • Accurate characterization of breast lesions is crucial for diagnosis.
  • Minimally invasive techniques are preferred for breast biopsies.
  • Near-infrared photon migration spectroscopy offers potential for tissue analysis.

Purpose of the Study:

  • To develop and evaluate a novel fiber-optic probe for in-situ optical sampling during breast needle biopsies.
  • To assess the probe's capability in measuring optical properties of simulated breast lesions.

Main Methods:

  • Development of a 2.3-mm-diameter fiber-optic probe compatible with biopsy needles.
  • Testing the probe using tissue phantoms with embedded heterogeneities of varying sizes and optical properties.

Related Experiment Videos

  • Utilizing near-infrared photon migration spectroscopy for optical measurements.

    • Main Results:

    • The fiber-optic probe can be inserted via standard biopsy needles.
    • Accurate measurement of absorption coefficients (within 30%) for heterogeneities as small as 10 mm was achieved.
    • The system demonstrated feasibility for optical sampling of simulated lesions.

    Conclusions:

    • The developed fiber-optic probe is suitable for in-vivo optical measurements during breast needle biopsies.
    • This technology can enhance the diagnostic capabilities of breast needle biopsies.
    • Further clinical validation is warranted to assess its utility in real-world scenarios.