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Visible Human 2.0--the next generation.

Peter Ratiu1, Berend Hillen, Jack Glaser

  • 1Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA.

Studies in Health Technology and Informatics
|October 1, 2004
PubMed
Summary
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New anatomical imaging techniques create a high-resolution, continuous data set from radiology to histology. This bridges the gap between gross anatomy and cellular detail for enhanced medical research and simulation.

Area of Science:

  • Anatomical imaging
  • Medical visualization
  • Digital anatomy

Background:

  • Existing anatomical data sets like the Visible Human Male and Female have limitations with artifacts and resolution.
  • There is a need for higher resolution anatomical data to bridge the gap between gross anatomy and histology.

Purpose of the Study:

  • To develop new anatomical methods for acquiring higher resolution data sets.
  • To address artifacts and enhance structure detection in anatomical data.
  • To create a continuum of anatomical data from radiological to microscopic resolutions.

Main Methods:

  • Acquisition of a complete head and neck data set.
  • CT and MR scans with registration hardware.
  • Injection of arterial and venous systems with colorized araldite-F.

Related Experiment Videos

  • Axial cryosectioning and digital photography at 147 microns/voxel resolution.
  • Special tissue harvesting, staining, and scanning at 2 microns/pixel resolution using Virtual Slice technology.

    • Main Results:

    • A complete anatomical data set of the head and neck was acquired.
    • Data spans radiological (1 mm/voxel), macroscopic (0.147 mm/voxel), and microscopic (2 microns/pixel) resolutions.
    • This represents the first continuum of anatomical data from gross to cellular levels.

    Conclusions:

    • The presented data set bridges the gap between gross anatomy and histology.
    • Enables seamless study of organs at a cellular level.
    • Provides a testbed for validating histological estimation techniques.
    • Paves the way for a future Visible Human at cellular resolution for advanced medical research and simulation.