Impact of the magnitude of the initial ST-segment elevation on left ventricular function in patients with anterior

Related Experiment Video

Updated: Aug 21, 2026

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs
08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Satoshi Kurisu1, Ichiro Inoue, Takuji Kawagoe

  • 1Department of Cardiology, Hiroshima City Hospital, Japan. skurisu@nifty.com

Circulation Journal : Official Journal of the Japanese Circulation Society
|October 2, 2004
PubMed

Insights

Initial ST-segment elevation magnitude predicts left ventricular function in acute myocardial infarction patients with total coronary occlusion, but not with spontaneous reperfusion. Higher ST elevation indicates poorer outcomes in total occlusion.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Imaging

Background:

  • The impact of initial ST-segment elevation magnitude on left ventricular (LV) function after acute myocardial infarction (AMI) during percutaneous coronary intervention (PCI) is not fully understood.
  • Assessing ST-segment elevation's role in LV function is crucial for understanding AMI pathophysiology and prognosis.

Purpose of the Study:

  • To investigate the relationship between the magnitude of initial ST-segment elevation and early left ventricular ejection fraction (LVEF) in patients with anterior AMI.
  • To determine if this relationship differs between patients with total coronary occlusion and those with spontaneous reperfusion.

Main Methods:

  • Evaluated 239 patients with total occlusion and 81 with spontaneous reperfusion within 12 hours of anterior AMI.
  • Measured the sum of ST-segment elevation (SigmaST) before angiography.
  • Assessed predischarge LVEF at 15±5 days post-PCI.

Main Results:

  • In total occlusion, lower predischarge LVEF was observed in patients with SigmaST ≥10 mm compared to those with SigmaST <10 mm (51±14% vs 57±14%, p<0.01).
  • In spontaneous reperfusion, no significant LVEF difference was found based on SigmaST magnitude (61±13% vs 62±14%, p=NS).
  • Predischarge LVEF correlated negatively with SigmaST in total occlusion (r=-0.25, p<0.01) but not in spontaneous reperfusion (r=0.03, p=NS).

Conclusions:

  • Initial ST-segment elevation magnitude is a significant predictor of LV function in AMI patients with total coronary occlusion.
  • ST-segment elevation magnitude does not predict LV function in AMI patients with spontaneous reperfusion.
Abstract

More Related Videos

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in G&#246;ttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...