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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
Published on: July 18, 2025
920
Metabolic storage diseases: amyloidosis
Elizabeth M Brunt1, Dina G Tiniakos
1Department of Pathology, Saint Louis University School of Medicine, 4(th) Floor, SLUH, 3635 Vista Avenue, St. Louis, MO 63110, USA. bruntem@slu.edu
Clinics in Liver Disease
|October 7, 2004
Summary
This review covers amyloidosis, focusing on hepatic amyloidosis. It details the disease's progression, diagnosis, and treatment, highlighting liver involvement
Area of Science:
- Medicine
- Pathology
- Gastroenterology
Background:
- Amyloidosis is a complex disease characterized by protein misfolding and deposition.
- Hepatic amyloidosis presents a spectrum of clinical significance, from incidental findings to indicators of systemic disease.
Purpose of the Study:
- To provide a comprehensive overview of amyloidosis, with a specific focus on hepatic involvement.
- To discuss the pathogenesis, epidemiology, clinical presentation, and management strategies for amyloidosis.
Main Methods:
- Literature review of current concepts in amyloidosis.
- Synthesis of information on pathogenesis, epidemiology, clinical significance, and treatment.
Main Results:
- Hepatic amyloidosis can range from histologically insignificant to a marker of poor prognosis.
- Key clinical features and diagnostic clues for amyloidosis are presented.
Conclusions:
- Accurate diagnosis and understanding of hepatic amyloidosis are crucial for patient management.
- Histologic confirmation is important, though liver biopsy remains a subject of debate.
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