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Related Experiment Videos

Laryngeal chemosensory clusters.

Andrea Sbarbati1, Flavia Merigo, Donatella Benati

  • 1Department of Morphological-Biomedical Sciences, Human Anatomy and Histology Section, University of Verona, Italy. andrea.sbarbati@univr.it.

Chemical Senses
|October 7, 2004
PubMed
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Chemosensory clusters (CCs) in the larynx express taste signaling molecules like alpha-gustducin and PLCbeta2. These laryngeal CCs differ structurally from lingual taste buds, suggesting a link between taste and solitary chemosensory cells.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Sensory Biology

Background:

  • Taste signaling molecules, including taste receptors (TRs), alpha-gustducin, PLCbeta2, and IP3R3, are found in lingual taste buds and solitary chemoreceptor cells.
  • These molecules mediate the sense of taste and chemoreception in various organs.

Purpose of the Study:

  • To investigate the presence and characteristics of chemosensory cells at the laryngeal inlet.
  • To compare laryngeal chemosensory structures with lingual taste buds.

Main Methods:

  • Immunocytochemical staining using light and electron microscopy.
  • Antibodies targeting alpha-gustducin and PLCbeta2 were employed.

Main Results:

  • Alpha-gustducin and PLCbeta2 were localized in chemosensory clusters (CCs) at the laryngeal inlet.

Related Experiment Videos

  • Laryngeal CCs are smaller, composed of fewer cells (2-3), and structurally distinct from lingual taste buds.
  • Laryngeal chemosensory cells exhibit unique morphological features, including shorter apical and basal processes and a flask-like shape in some instances.
  • Laryngeal CCs lack pores and have less distinct boundaries compared to lingual taste buds.

    • Conclusions:

    • The identification of CCs in the larynx provides evidence for chemosensory functions beyond the oral cavity.
    • The distinct morphology of laryngeal CCs suggests specialized adaptations.
    • These findings support a phylogenetic relationship between gustatory and solitary chemosensory cells.