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Updated: Aug 21, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Are there genetic influences on sporadic brain arteriovenous malformations?
William L Young1, Guo-Yuan Yang
1Department of Anesthesia, Center for Cerebrovascular Research, Neurological Surgery, and Neurology, University of California San Franscisco, 1001 Potrero Ave, Box 1371 San Francisco, CA 94110, USA. ccr@anesthesia.ucsf.edu
Abstract:
The genesis of brain arteriovenous malformations remains enigmatic. We reviewed some pathways involving inflammatory and angiogenic signals that are amenable to the study of genetic single-nucleotide polymorphisms associated with the sporadic disease. Such study can yield insights into arteriovenous malformation pathogenesis and suggest possible fruitful approaches to developing medical therapy. Moreover, single-nucleotide polymorphisms identification would provide targets for risk stratification for planning clinical trials and eventually guiding management.
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