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How the mouse got its spots.

Marnie E Blewitt1, Suyinn Chong, Emma Whitelaw

  • 1School of Molecular and Microbial Biosciences, University of Sydney, 2006 NSW, Australia.

Trends in Genetics : TIG
|October 12, 2004
PubMed
Summary
This summary is machine-generated.

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Developmental noise, a key factor in phenotype variation, may stem from the genome's epigenetic state. This epigenetic basis, established during embryonic development, explains how intangible variation arises and persists throughout life.

Area of Science:

  • Genetics and Epigenetics
  • Developmental Biology

Background:

  • Phenotype results from genotype, environment, and developmental noise.
  • Developmental noise significantly contributes to trait variation but its molecular basis is unknown.
  • This intangible variation is established during embryonic development and retained lifelong.

Purpose of the Study:

  • To propose a molecular basis for developmental noise.
  • To investigate the role of epigenetic state in developmental noise.

Main Methods:

  • Review of existing literature on phenotype variation and developmental noise.
  • Hypothesizing the epigenetic state as the source of developmental noise.

Main Results:

  • Developmental noise contributes significantly to quantitative trait variance.

Related Experiment Videos

  • The epigenetic state of the genome is proposed as a molecular basis for developmental noise.
  • Stochastic epigenetic state establishment and mitotic heritability provide components for developmental noise.

    • Conclusions:

    • Epigenetic state is a likely molecular basis for developmental noise.
    • This mechanism explains the persistence of intangible variation from embryonic development.
    • Understanding developmental noise is crucial for a complete picture of phenotype determination.