[Toxico-pharmacologic study of a curarimimetic, AH 8165, in relation to storage time]

The toxicological and pharmacological study of a non depolarizing curariform drug AH 8165 was performed under various conditions of storage, duration and temperature (duration: 1 month 2 years; temperature: 4 degrees C to 70 degrees C). It shows that this drug ought to be kept a low temperature for storage (in the range of + 4 degrees C). In the sam way, this study demonstrates a better stability of this drug when stored lyophilized form instead of a solute. The interest of standardized animal experimentation in studying the activity of a therapeutic substance depending on the duration of storage is shown.