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Updated: Aug 21, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
Published on: September 14, 2016
Derivation of hyperbolic models for chemosensitive movement
Francis Filbet1, Philippe Laurençot, Benoît Perthame
1Mathématiques et Applications, Physique Mathématique d'Orléans, CNRS UMR 6628, Université d'Orléans, B.P. 6759, 45067 Orléans cedex 2, France. filbet@labomath.univ-orleans.fr
Abstract:
A Chapman-Enskog expansion is used to derive hyperbolic models for chemosensitive movements as a hydrodynamic limit of a velocity-jump process. On the one hand, it connects parabolic and hyperbolic chemotaxis models since the former arise as diffusion limits of a similar velocity-jump process. On the other hand, this approach provides a unified framework which includes previous models obtained by ad hoc methods or methods of moments. Numerical simulations are also performed and are motivated by recent experiments with human endothelial cells on matrigel. Their movements lead to the formation of networks that are interpreted as the beginning of a vasculature. These structures cannot be explained by parabolic models but are recovered by numerical experiments on hyperbolic models. Our kinetic model suggests that some kind of local interactions might be enough to explain them.
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