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Updated: Aug 21, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
Jae-Chul Jung1, Ji-Ho Lee, Seikwan Oh
1Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, PO Box 1848, University, MS 38677-1848, USA.
Abstract:
A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.
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