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Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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Related Experiment Video

Updated: Jun 22, 2026

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

Newly acquired left bundle-branch block: the Framingham study.

J F Schneider, H E Thomas, B E Kreger

    Annals of Internal Medicine
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Newly acquired left bundle-branch block (LBBB) often signals underlying heart disease. This condition significantly increases the risk of developing coronary disease, heart failure, and cardiovascular death.

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    Published on: July 20, 2022

    Area of Science:

    • Cardiology
    • Clinical Medicine
    • Epidemiology

    Background:

    • Left bundle-branch block (LBBB) is a recognized electrocardiographic finding.
    • Its prognostic significance, particularly when newly acquired, requires further elucidation.

    Purpose of the Study:

    • To prospectively examine the clinical implications and long-term outcomes of newly acquired left bundle-branch block (LBBB).

    Main Methods:

    • Prospective observational study within the Framingham Study population.
    • Long-term follow-up (18 years) of individuals who developed new-onset LBBB.
    • Comparison with age- and sex-matched control subjects without LBBB.

    Main Results:

    • Newly acquired LBBB occurred in 55 individuals, with a mean age of 62.
    • LBBB was associated with antecedent hypertension, cardiac enlargement, and coronary heart disease.
    • 48% developed new coronary disease or congestive failure post-LBBB onset.
    • Within 10 years, 50% of individuals with new LBBB died from cardiovascular diseases.
    • LBBB independently increased cardiovascular mortality risk in men.

    Conclusions:

    • Newly acquired LBBB is a marker of advanced hypertensive or ischemic heart disease.
    • It portends a poor prognosis with high rates of subsequent cardiovascular events and mortality.
    • Early identification and management of underlying cardiovascular conditions are crucial in patients with new LBBB.