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Published on: June 13, 2025
[Meningitis due to Pseudomonas stutzeri: a case report]
Nuriye Taşdelen Fişgin1, Ibrahim Cağatay Acuner, Ahmet Yilmaz Coban
1Ondokuz Mayis Universitesi Tip Fakültesi, infeksiyon Hastaliklari ve Klinik Mikrobiyoloji Anabilim Dali, Samsun.
Abstract:
Pseudomonas stutzeri is a saprophytic microorganism that rarely causes severe infections. In this report, a 28 days old male patient with meningomyelocele at birth was presented. The patient was admitted to the hospital with fever, and diagnosed as meningitis on the basis of physical examination and leukocytosis (blood: 16.380/mm3, cerebrospinal fluid (CSF): 130/mm3; 90% PMNL). Following diagnosis ceftriaxone therapy was started led to improvement in clinical and laboratory findings. However on the 20th day, the clinical signs and symptoms became worse, and the patient was diagnosed to develop a second meningitis attack by laboratory examination of CSF. P. stutzeri was isolated from the CSF culture, and the isolate was found to be resistant to ceftriaxone. Upon this result the therapy has changed to meropenem. On the 5th day of the therapy, the patient has slightly improved and he was discharged due to the wishes of his parents, however he died two days after discharge. This first case of P. stutzeri meningitis in neonates was presented to withdraw attention to this clinical entity.
Insights
This case report details the first instance of Pseudomonas stutzeri meningitis in a neonate. The rare bacterial infection, resistant to initial treatment, highlights the need for awareness in neonatal intensive care units.
Area of Science:
- Medical Microbiology
- Neonatal Infectious Diseases
Background:
- Pseudomonas stutzeri is typically a harmless, saprophytic bacterium.
- Severe infections caused by P. stutzeri are uncommon, particularly in neonates.
Observation:
- A 28-day-old male infant with a history of meningomyelocele presented with fever and meningitis.
- Initial treatment with ceftriaxone showed temporary improvement.
- A secondary meningitis attack occurred, with P. stutzeri isolated from cerebrospinal fluid (CSF).
Findings:
- The P. stutzeri isolate demonstrated resistance to ceftriaxone.
- Therapy was switched to meropenem, resulting in slight clinical improvement.
- The infant was discharged against medical advice and later died.
Implications:
- This case represents the first documented instance of P. stutzeri meningitis in a neonate.
- Highlights the potential for rare pathogens to cause severe neonatal infections.
- Emphasizes the importance of considering unusual bacterial causes of meningitis in neonates, especially those with underlying conditions.
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