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Related Experiment Videos

Intramuscular arteether for treating severe malaria.

B B Afolabi1, C N Okoromah

  • 1Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria. bosedeafolabi2003@yahoo.com

The Cochrane Database of Systematic Reviews
|October 21, 2004
PubMed
Summary

Intramuscular arteether shows no significant difference in mortality or neurological complications compared to quinine for severe malaria in children. More extensive trials are necessary to confirm arteether

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Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe malaria treatment relies on quinine and artemisinin drugs.
  • Increasing quinine resistance necessitates alternative treatments.
  • Arteether, an artemisinin derivative, offers improved stability and a longer half-life.

Purpose of the Study:

  • To evaluate the efficacy and safety of intramuscular arteether versus other antimalarial drugs for severe malaria.

Main Methods:

  • Systematic review and meta-analysis of randomized and quasi-randomized controlled trials.
  • Searched multiple databases (Cochrane, MEDLINE, EMBASE, etc.) up to August 2004.
  • Included trials involving adults and children with severe malaria treated with intramuscular arteether.

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Main Results:

  • Two small trials (n=194) compared arteether with quinine in children with cerebral malaria.
  • No statistically significant differences were found in mortality, neurological complications, or time to consciousness, parasite, and fever clearance.
  • Current meta-analyses lack the statistical power to detect clinically significant differences.

Conclusions:

  • Further large-scale clinical trials are required to establish the efficacy and safety of arteether for severe malaria.
  • Current evidence is insufficient to draw firm conclusions on arteether's role in malaria treatment.