[Treatment of primary and regional melanoma]

The treatment of primary melanoma and regional melanoma remains essentially the surgery. At the stage of primary tumor, the treatment is established from the data of the conference of consensus of 1995. In addition, at this stage of primary tumor, when the index of Breslow of the melanoma is equal or higher than 1.5 mm like at the stage of lymph node invasion, an adjuvant treatment by interferon alpha after the surgery must be discussed. Chemotherapy on the other hand never proved reliable of its effectiveness as adjuvant treatment. In the future, the approaches by vaccination and cellular therapy could be interesting at these stages of the disease.