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Updated: Aug 21, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Asymmetric catalytic synthesis of enantiopure N-protected 1,2-amino alcohols
Giuseppe Bartoli1, Marcella Bosco, Armando Carlone
1Department of Organic Chemistry A. Mangini, University of Bologna v.le Risorgimento 4, 40136 Bologna, Italy. giuseppe.bartoli@unibo.it
Abstract:
[reaction: see text] The asymmetric aminolytic kinetic resolution (AKR) of racemic terminal epoxides using carbamates as the nucleophile catalyzed by (salen)Co(III) complex provides a practical and straightforward method for the synthesis of both aliphatic and aromatic N-Boc- or N-Cbz-protected 1,2-amino alcohols in almost enantiomerically pure form (ee >/= 99%). The AKR uses an easily accessible catalyst and inexpensive starting materials, and the reactions are conveniently carried out at room temperature under an air atmosphere.
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