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Updated: Aug 12, 2026
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[Expression of cyclooxygenase-2 and p53 and their correlation in carcinoma of larynx]
1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective:
To study the expression of cyclooxygenase-2 in laryngeal squamous carcinoma and evaluate the relation between cyclooxygenase-2 and p53.
Method:
The pathological sections of laryngeal squamous carcinoma was examined by using the method of immunohistochemistry.
Result:
Overexpression of Cox-2 and p53 were found in the laryngeal squamous carcinoma specimens; the positive rates of cyclooxygenase-2 and p53 protein expression were 58.7% (37/63) and 63.5% (40/63), respectively. The positive expressions of Cox-2 were related to the clinical stage. The positive expressions of p53 were related to histological grade. There was a positive relationship between Cox-2 and p53.
Conclusion:
Cyclooxygenase-2 plays an important roles in the process of development, growth and invasion of laryngeal squamous carcinoma; and its inhibitors maybe have effect on the development of laryngeal squamous carcinoma.
