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Updated: Aug 21, 2026
Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina
Published on: February 13, 2021
High-resolution imaging of living retina through optic adaptive retinal imaging system
Chunhui Jiang1, Wenji Wang, Ning Ling
1Eye ENT Hospital of Fudan University, Shanghai 200031, China.
Purpose:
To evaluate the possibility as well as the usage of adaptive optics in high-resolution retinal imaging.
Methods:
From March to November 2001, the fundus of 25 adults were checked by using Optic Adaptive Retinal Imaging System (OAS). The age of the subjects varied from 18 - 48 years. All had normal visual acuity from 0.9 to 1.0. No abnormality was found in the ocular examination, and their medical as well as ocular history was unremarkable.
Results:
High-resolution images of the retinal cells, photoreceptor and bipolar cell, were analysed. In these images, the cells are clearly resolved. The density of the photoreceptor at area 1.5 degree from the foveloa is around 40 000 - 50 000/mm2. At area 3 degree, it drops to less than 30 000/mm2.
Conclusion:
Optic Adaptive Retinal Imaging System (AOS) is able to get high-resolution image of retinal cells in living human eyes. It may be widely used in ophthalmology experimentally and clinically.
