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Updated: Aug 21, 2026
Transretinal ERG Recordings from Mouse Retina: Rod and Cone Photoresponses
Published on: March 14, 2012
Exploration of multifocal rod electroretinograms recording in human
Changzheng Chen1, Lezheng Wu, De-Zheng Wu
1Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Purpose:
To test the feasibility of recording rod multifocal electroretinograms (ERG) in humans and observe appropriate recording conditions.
Methods:
Multifocal rod ERG were recorded using a stimulus array of 61 equalsized hexagons in two normal subjects after the dark adaptation. Flashes were blue (W47B). Blank frames between two successive flashes of hexagons varied from 0 to 14. Length of the m-sequence, bandwidth, flash frequency, flash intensities and background intensities were changed to obtain appropriate recording conditions for the clinical use.
Results:
Multifocal rod ERG were clearly recordable and well formed. They had an early implicit time, very small negative wave and a late implicit time, large positive wave. The positive wave was bimodal, whose timing and waveform were similar to the full-field rod ERG. The local response amplitudes can be suppressed with increase in flash frequency or background intensity, decrease in flash intensity or the size of stimulus elements.
Conclusions:
Multifocal rod ERG can be recorded in human and can provide topographical maps of retinal function that have clinical usage. 2(12)-1 m-sequence length, 3F blank frames and 3 - 300 Hz bandwidth were suggested to appropriate recording conditions.
