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Updated: Aug 15, 2026

Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
Published on: January 14, 2014
Changes in hemodynamics and respiration in rats with different resistance to acute hypoxia
N V Sanotskaya1, D D Matsievskii, M A Lebedeva
1Laboratory of Respiration Pathophysiology, Bioengineering Laboratory, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Abstract:
Effects of acute hypoxia on hemodynamics and respiration were studied in acute experiments on narcotized rats. The animals were divided into groups characterized by high, low-, and medium- resistance to hypoxia by the time of respiration arrest during inhalation of gas mixture containing 3% O2. Hemodynamic parameters of highly resistant animals were higher than in low-resistant rats throughout the entire hypoxic period. The development of a rare (with prolonged inspiratory phase) respiratory rhythm in highly resistant rats is an adaptive reaction, which allows them longer tolerate hypoxia compared to low-resistant animals.
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