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Updated: Aug 21, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
Echogenic substantia nigra in patients with orthostatic tremor
1Department of Neurology, University of the Saarland, Homburg, Saar, Germany. nejspi@uniklinik-saarland.de
Objectives:
Previous studies suggest that the nigrostriatal dopaminergic transmission is impaired in patients with primary orthostatic tremor.
Methods:
We used transcranial sonography (TCS) to examine the morphology of the substantia nigra (SN) in four patients with primary orthostatic tremor (OT).
Results:
TCS revealed an SN echogenicity in all patients, in three patients unilaterally, in one patient bilaterally.
Conclusions:
Our data suggest nigrostriatal dopaminergic deficits in OT patients. The exact impact of these dopaminergic deficits on OT generation is unclear.
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