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Effects of Atorvastatin on some inflammatory parameters in severe primary hypercholesterolemia

Minodora Dobreanu1, Catrinel Gălăţeanu, Agneta Simionescu

  • 1Department of Clinical Biochemistry, U.M.P. Tîrgu Mureş, Gh. Marinescu 38, 4300 Tîrgu Mureş.

Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
|November 6, 2004
PubMed

Insights

Atorvastatin significantly reduced LDL cholesterol and inflammatory markers like CRP and homocysteine in patients with severe primary hypercholesterolemia. These anti-inflammatory effects may contribute to clinical benefits beyond cholesterol lowering.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Emerging evidence links atherosclerosis, inflammation, and hypercholesterolemia.
  • Severe primary hypercholesterolemia (PHC) presents significant cardiovascular risk.
  • Statins, HMG CoA reductase inhibitors, are primary treatments for hypercholesterolemia.

Purpose of the Study:

  • To investigate the influence of Atorvastatin on inflammatory parameters in patients with severe PHC.
  • To assess Atorvastatin's effects on serum lipids, apoproteins, and specific inflammatory markers.
  • To evaluate potential anti-inflammatory mechanisms of statin therapy.

Main Methods:

  • A study involving 21 patients with severe PHC, 12 with significant coronary-artery stenosis.
  • Baseline measurements included lipids, apoproteins, CRP, sICAM, lipid peroxides, Ab oxLDL, and homocysteine.
  • Patients received Atorvastatin 40 mg daily for 8 weeks after a 4-week baseline period.

Main Results:

  • Atorvastatin significantly reduced LDL-C (57.8%), total Cholesterol (44.08%), Apo B (50.6%), and TG.
  • In patients with coronary heart disease, Atorvastatin decreased homocysteine (19.41%) and CRP (21.9%).
  • Atorvastatin reduced lipid peroxides (TBARS) by 52% but did not significantly affect sICAM or Ab oxLDL.

Conclusions:

  • Atorvastatin effectively modulates LDL-C and exhibits anti-inflammatory effects, reducing CRP and homocysteine.
  • These anti-inflammatory actions may contribute to the clinical benefits of statins, independent of lipid-lowering.
  • Plaque stabilization through anti-inflammatory mechanisms is a potential key action of statin therapy.

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