Related Experiment Videos

[Case report of Rosai-Dorfman disease mimicking pachymeningitis]

Yoshimasa Kinoshita1, Hideoki Yasukouchi, Eichi Tsuru

  • 1Department of Neurosurgery, Munakata Suikokai General Hospital, 341-1 Fukuma, Munakata, Fukuoka 811-3298, Japan. yosimasa@suikokai.or.jp

No Shinkei Geka. Neurological Surgery
|November 9, 2004
PubMed

Insights

Rosai-Dorfman disease (RDD), a rare histioproliferative condition, can manifest in the central nervous system. This case highlights an isolated intracranial dural-based RDD mimicking pachymeningitis.

Area of Science:

  • Neurology
  • Pathology
  • Oncology

Background:

  • Rosai-Dorfman disease (RDD) is a rare histioproliferative disorder typically affecting lymph nodes.
  • Extranodal involvement is known, but central nervous system (CNS) RDD is exceptionally uncommon.
  • This case focuses on an isolated, intracranial, dural-based presentation of RDD.

Observation:

  • A 69-year-old male presented with seizures.
  • High-resolution MRI revealed a thickened, stratified dura with cortical edema in the left frontal region.
  • Surgical resection showed proliferative histiocytes with emperipolesis, positive for S-100 protein.

Findings:

  • Histopathological examination confirmed Rosai-Dorfman disease.
  • The intracranial lesion mimicked pachymeningitis.
  • This represents a rare instance of isolated dural RDD.

Implications:

  • Highlights the importance of considering RDD in the differential diagnosis of dural-based intracranial masses.
  • Contributes to the understanding of rare CNS manifestations of Rosai-Dorfman disease.
  • Reviews previously reported cases of intracranial RDD to aid future diagnoses.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...