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[Clinical and immunological characteristics of HIV-positive AIDS in children in Northern Israel]

E Kedem1, A Etzioni, E Shahar

  • 1Institute of Immunology, Allergy and AIDS and Dept. of Pediatrics A, Rambam Medical Center and B. Rappaport Faculty of Medicine, The Technion, Haifa.

Harefuah
|November 10, 2004
PubMed

Insights

Early antiretroviral treatment and supportive care significantly improve outcomes for children with HIV/AIDS. This approach stabilizes immune function and enhances quality of life, contrasting with more rapidly progressive disease patterns in literature.

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Public health

Context:

  • Vertical transmission of Human Immunodeficiency Virus (HIV) remains a significant concern.
  • Management of pediatric Acquired Immunodeficiency Syndrome (AIDS) requires comprehensive care.
  • Zidovudine prophylaxis in pregnant, HIV-carrier mothers shows potential in preventing vertical transmission.

Purpose:

  • To evaluate the clinical status and treatment outcomes of children with HIV/AIDS.
  • To assess the impact of combined antiretroviral therapy and opportunistic infection prophylaxis.
  • To investigate factors contributing to disease progression and clinical well-being.

Summary:

  • Eleven children with HIV/AIDS, infected via vertical transmission, were treated with a combination of 2-3 antiretroviral drugs.
  • 8/11 children received prophylactic treatment for opportunistic infections, and 8/11 are clinically well.
  • Despite moderate to severe immunodeficiency, CD4+ cell counts remained stable over an average 28-month follow-up, suggesting treatment efficacy.

Impact:

  • Aggressive medical and supportive treatment, including regular follow-up and family engagement, improves clinical condition and quality of life in pediatric HIV/AIDS.
  • The study highlights a lower rate of rapidly progressive disease (60%) compared to literature (10-15%) in this cohort, potentially due to early and comprehensive intervention.
  • Effective management strategies can lead to stable disease markers and improved patient outcomes in pediatric HIV/AIDS care.

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