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Updated: Aug 21, 2026

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
Published on: February 16, 2024
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose
Olaf Hoffmann1, L Rolf Gommert, Martin Egert
1Department of Neurology, Charité-Hochschulmedizin, Berlin, Germany. hoffmann@charite.de
Abstract:
We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug. Typically, flupirtine exerts membrane stabilizing and hyperpolarizing effects through activation of neuronal G-protein regulated inwardly rectifying potassium channels (GIRK). Based on these properties, GIRK activators have been suggested as candidates for antiepileptic drug development. In contrast, our observation suggests that these substances may also display unexpected proconvulsant effects in vivo.
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