Related Experiment Video
Updated: Aug 21, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
Combined reconstruction of the diabetic foot including revascularization and free-tissue transfer
N A C Verhelle1, V Lemaire, X Nelissen
1Department of Maxillofacial, Hand, and Plastic and Reconstructive Surgery, CHU Sart Tilman, University of Liège, Belgium.
Abstract:
Diabetic patients, presenting with both peripheral vascular disease and large soft-tissue defects, are too often treated by primary amputation. A combined revascularization and free-tissue transfer procedure can extend limb salvage in these patients. The authors report their experience over 4 years with 19 diabetic patients with peripheral vascular disease and large soft-tissue defects of the foot requiring free-tissue transfer. Although there was a 100 percent flap survival, early local wound problems occurred in three patients (16.6 percent). The recurrence rate was about 18.7 percent, but no complementary flap procedures were mandatory. With a mean follow-up of 38 months (range: 23 to 55 months), the limb salvage rate was 94.4 percent. Although there was one limb loss and one patient with ambulation difficulties, 16 patients (84.2 percent) were fully rehabilitated and were able to function independently. Despite a rather small series, this study confirms that in selected diabetic patients, a combined approach of vascular and reconstructive surgeons can reduce the limb amputation rate with acceptable complication rates. This combined approach offers major benefits to these patients, especially stable coverage and preservation of ambulation, and should always be considered before amputation.
Related Concept Videos
Diabetic Foot Ulcer
Peripheral Artery Disease V: Postoperative Nursing Management
Diabetic Retinopathy
Peripheral Artery Disease III: Interprofessional Care