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Corticosteroids: the mainstay in asthma therapy
Ranju Gupta1, Dharam Paul Jindal, Gulshan Kumar
1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India. ranju29in@yahoo.co.in
Bioorganic & Medicinal Chemistry
|November 24, 2004
Summary
Corticosteroids are the primary treatment for asthma, effectively managing inflammation. Inhaled corticosteroids are preferred for chronic use due to lower toxicity, while oral forms treat severe exacerbations.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Pharmacology
Background:
- Inflammation is a key factor in asthma pathophysiology.
- Current asthma management targets both symptoms and underlying inflammation.
Purpose of the Study:
- To review the role of corticosteroids in asthma management.
- To highlight the benefits of inhaled corticosteroids (ICS) over oral formulations.
Main Methods:
- Review of current literature on asthma pathophysiology and treatment.
- Analysis of the efficacy and safety profiles of corticosteroids.
Main Results:
- Corticosteroids are the most potent anti-inflammatory agents for asthma.
- Inhaled corticosteroids offer reduced systemic toxicity compared to oral glucocorticoids.
- ICS are recommended as monotherapy for most asthma patients.
Conclusions:
- Corticosteroids, particularly inhaled forms, remain the cornerstone of asthma therapy.
- Combination therapy with other agents may be considered for severe asthma.
- Developing novel asthma therapies has proven challenging compared to ICS.
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