Related Experiment Video

Updated: Aug 20, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

[Sickle cell disease pathophysiology: from theoretical to practical aspects]

Frédéric Galactéros1

  • 1Unité des maladies génétiques du globule rouge, hôpital Henri Mondor, 94010 Créteil. frederic.galacteros@hmn.aphp.fr

La Revue Du Praticien
|November 24, 2004
PubMed

Insights

Understanding sickle cell disease (SCD) pathophysiology requires integrating molecular, cellular, vascular, and genetic data. This approach supports new therapeutic strategies for SCD, though this manuscript focuses on basic pathophysiology.

Area of Science:

  • Hematology
  • Genetics
  • Molecular Biology

Context:

  • Sickle cell disease (SCD) pathophysiology is complex, involving molecular, cellular, and vascular factors.
  • A comprehensive understanding is crucial for developing effective treatments.
  • Current research highlights the need for integrating diverse data domains.

Purpose:

  • To provide an updated understanding of sickle cell disease pathophysiology.
  • To explore the molecular, cellular, vascular, and genetic underpinnings of SCD.
  • To lay the groundwork for future therapeutic advancements.

Summary:

  • This manuscript focuses on the elementary pathophysiology of sickle cell disease.
  • It emphasizes the need for a comprehensive approach integrating molecular, cellular, vascular, and genetic data.
  • The study acknowledges limitations in covering tissue-specific or systemic complications.

Impact:

  • Advances the fundamental knowledge of sickle cell disease mechanisms.
  • Informs the development of novel therapeutic strategies for SCD.
  • Highlights areas for future research in SCD complications.

More Related Videos

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases11:08

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...