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[Current therapeutic approach in atopic eczema]
1Medizinischen Akademie Carl Gustav Carus, Dresden.
Summary
Systemic treatments are crucial for severe atopic eczema unresponsive to topical therapies. This review covers methods like fatty acid substitution, UV therapy, and Cyclosporin A, targeting inflammatory infiltrates.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Context:
- Severe and recalcitrant atopic eczema often necessitates systemic interventions beyond conventional topical treatments.
- Understanding the limitations of topical therapies is key to exploring advanced treatment modalities.
Purpose:
- To review established and emerging systemic treatment options for severe atopic eczema.
- To discuss therapeutic strategies targeting the underlying inflammatory processes in atopic eczema.
Summary:
- Discusses systemic treatments for severe atopic eczema, including gamma-linoleic acid and eicosapentaenoic acid substitution, specific UV-irradiation, and Cyclosporin A.
- Highlights therapeutic approaches aimed at modulating the atopic inflammatory infiltrate.
Impact:
- Provides a consolidated overview of systemic treatment options for clinicians managing difficult-to-treat atopic eczema.
- Informs future research directions for novel therapies targeting atopic eczema's inflammatory pathways.