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Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
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[Influence of acute hemorrhage on erythrodieresis]

E K Golubeva, S B Nazarov, M V Kazak

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |November 24, 2004
    PubMed

    Influence of acute hemorrhage on peritoneal and splenic macrophages function and NO production was studied. Interaction of peritoneal and splenic macrophages with autologous erythrocytes was examined the day after the hemorrhage. Concentration of nitrate ions: the stable metabolites of nitric oxide, was measured in peritoneal lavage, splenic cells suspension, blood, as well as in supernatant of peritoneal and splenic macrophages before and after hemorrhage. The data obtained suggest that splenic macrophages of intact rats are more active than peritoneal ones. After hemorrhage peritoneal macrophages activity increases, whereas splenic macrophages remain unchanged. Concentration of nitrate ions is significantly reduced after hemorrhage.

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