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Prognostic factors in well-differentiated thyroid carcinoma
Sharon L Cushing1, Carsten E Palme, Nathalie Audet
1Department of Otolaryngology, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5.
The Laryngoscope
|November 27, 2004
Summary
Well-differentiated thyroid carcinoma (WDTC) has a notable recurrence rate but generally good survival. Key prognostic factors for recurrence include family history, advanced stage, and total thyroidectomy.
Area of Science:
- Endocrinology
- Oncology
- Surgical Oncology
Background:
- Well-differentiated thyroid carcinoma (WDTC) represents the majority of thyroid malignancies.
- Understanding prognostic factors is crucial for effective patient management and treatment strategies.
Purpose of the Study:
- To evaluate the prognostic significance of standard clinicopathologic factors in patients diagnosed with WDTC.
- To identify predictors of disease recurrence and survival in WDTC patients.
Main Methods:
- Retrospective chart review of 333 patients treated for WDTC between 1963 and 2000.
- Inclusion criteria required a minimum 5-year follow-up period.
- Analysis focused on recurrence rates, and 20-year overall and disease-specific survival.
Main Results:
- The recurrence rate for WDTC was 15.6% over the study period.
- Twenty-year disease-specific survival was 93.3%, with overall survival at 88.4%.
- Significant predictors of recurrence included family history of WDTC, advanced stage, and total thyroidectomy (P < .05). Advanced stage also predicted poorer disease-specific survival.
Conclusions:
- WDTC exhibits a significant recurrence rate but favorable long-term disease-specific survival.
- Family history, advanced initial stage, and total thyroidectomy are critical prognostic indicators.
- Age 60 or older showed a trend towards impacting disease-specific survival.