Enhanced release of lipase from stimulated mouse spleen cells

We detected lipase activity in an homogenate of mouse spleen- and lymph node cells by using [3H]-triolein as a lipase substrate. Lipase activity was also detected in an homogenate of human peripheral blood lymphocytes. Furthermore, in mouse spleen cell culture medium we observed increased lipase activity following stimulation of mouse spleen cells with phytohaemagglutinin (PHA) as well as allogeneic spleen cells. Therefore, we suggest that lipase may be a kind of lymphokine.