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Spasmolytic stilbenoids from Maxillaria densa.

S Estrada1, J J López-Guerrero, R Villalobos-Molina

  • 1Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Colonia Chamilpa, 62210, Cuernavaca, Morelos, México.

Fitoterapia
|November 30, 2004
PubMed
Summary
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Five stilbenoids from Maxillaria densa demonstrated potent smooth muscle relaxant effects on rat ileum contractions. Their mechanism does not appear to involve direct nitrergic, antihistaminergic, or calcium channel blocking actions.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Physiology

Background:

  • Maxillaria densa is a plant source of bioactive compounds.
  • Stilbenoids are a class of natural products with diverse biological activities.
  • Rat ileum is a common model for studying smooth muscle function and spasmolytic agents.

Purpose of the Study:

  • To isolate and characterize stilbenoids from Maxillaria densa.
  • To evaluate the spasmolytic activity of isolated stilbenoids on rat ileum.
  • To investigate the mechanism of action of these stilbenoids.

Main Methods:

  • Isolation and purification of compounds from plant extract.
  • In vitro pharmacological assays on isolated rat ileum.
  • Assessment of relaxant effects on spontaneous and induced contractions.

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Main Results:

  • Five stilbenoids (1-5) were isolated and identified.
  • Compounds 1-5 exhibited concentration-dependent inhibition of rat ileum contractions.
  • Potency of inhibition was comparable to papaverine, a known spasmolytic.
  • The relaxant activity did not appear to be mediated by nitrergic, antihistaminergic pathways, or calcium influx inhibition.

Conclusions:

  • Stilbenoids from Maxillaria densa possess significant spasmolytic properties.
  • The mechanism of action is likely novel and does not target common pathways.
  • Further research is warranted to elucidate the precise molecular targets.