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Published on: February 14, 2018

Therapy of systemic fungal infections

Jashin J Wu1, Katie R Pang, David B Huang

  • 1Department of Dermatology, University of California, Irvine, CA, USA.

Dermatologic Therapy
|December 2, 2004
PubMed

Insights

Systemic fungal infections are rising due to increased antibiotic use and vulnerable populations. This review covers key antifungal drug classes, including polyenes, imidazoles, and triazoles, for treating these infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Rising incidence of community-acquired and nosocomial fungal infections.
  • Key contributing factors include increased antibiotic usage, aging populations, and immunocompromised individuals (HIV, cancer, organ transplant recipients).

Purpose of the Study:

  • To review the indications, efficacy, and safety of systemic antifungal agents.
  • To discuss established drug classes and novel agents in development.

Main Methods:

  • Literature review of systemic antifungal medications.
  • Analysis of clinical data on polyenes, imidazoles, and triazoles.
  • Evaluation of emerging antifungal therapies.

Main Results:

  • Established antifungal classes demonstrate varying efficacy and safety profiles.
  • Newer agents are being developed to address resistance and improve outcomes.
  • Systemic fungal infections require careful management with appropriate antifungal selection.

Conclusions:

  • Antifungal stewardship is crucial given the increasing burden of fungal infections.
  • Continued research into novel antifungals is essential for combating resistant strains.
  • Understanding the pharmacodynamics and clinical utility of antifungals is vital for patient care.

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