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Infectious triggers of asthma
Ana L MacDowell1, Leonard B Bacharier
1Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine and St. Louis Children's Hospital, One Children's Place, St. Louis, MO 63110, USA.
Immunology and Allergy Clinics of North America
|December 8, 2004
Summary
Infections, particularly from viruses and atypical bacteria like Mycoplasma pneumoniae, frequently trigger asthma exacerbations. This review explores the link between infections and asthma, including its pathology and management.
Area of Science:
- Pulmonology
- Infectious Diseases
- Immunology
Background:
- Asthma exacerbations are commonly linked to infectious agents.
- Viruses are well-established triggers for asthma.
- Emerging evidence implicates atypical bacteria in asthma development and exacerbations.
Purpose of the Study:
- To review the evidence connecting specific infectious agents to asthma exacerbations.
- To examine the immunopathology underlying infection-triggered asthma.
- To discuss current therapeutic strategies for managing infection-induced asthma.
Main Methods:
- Literature review of studies on infectious agents and asthma.
- Analysis of immunopathological mechanisms.
- Evaluation of existing treatment options.
Main Results:
- Strong evidence supports viral infections as asthma exacerbation triggers.
- Mycoplasma pneumoniae and Chlamydia pneumoniae are increasingly recognized as potential asthma inciting and exacerbating agents.
- Understanding the immunopathology is crucial for effective management.
Conclusions:
- Infectious agents, including atypical bacteria, play a significant role in asthma exacerbations.
- Further research into the immunopathogenesis of infection-triggered asthma is warranted.
- Targeted therapies addressing infectious triggers may improve asthma management.