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Resistance training improves strength and functional capacity in persons with multiple sclerosis
L J White1, S C McCoy, V Castellano
1Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA. lwhite@hhp.ufl.edu
Multiple Sclerosis (Houndmills, Basingstoke, England)
|December 9, 2004
Summary
Progressive resistance training significantly improved lower extremity strength and stepping performance in multiple sclerosis (MS) patients. This eight-week program also reduced fatigue and tended to decrease disability.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Exercise Physiology
Background:
- Multiple sclerosis (MS) is a chronic neurological disease affecting ambulatory function and quality of life.
- Progressive resistance training (PRT) is a potential intervention to mitigate MS-related impairments.
Purpose of the Study:
- To assess the impact of an 8-week PRT program on lower extremity strength, ambulatory function, fatigue, and self-reported disability in MS patients.
Main Methods:
- Eight MS patients (mean disability score 3.7) underwent twice-weekly PRT targeting knee flexion, extension, and plantarflexion.
- Training intensity progressed from 50% to 70% of maximal voluntary contraction (MVC) over 8 weeks.
- Assessments included isokinetic dynamometry, MRI, walking speed, step count, and self-reported outcomes.
Main Results:
- Significant increases were observed in knee extension (7.4%), plantarflexion (52%), and stepping performance (8.7%) (P < 0.05).
- Self-reported fatigue significantly decreased (P < 0.05), and disability showed a trend towards reduction (P = 0.07).
Conclusions:
- MS patients can achieve positive adaptations through PRT.
- PRT is associated with improvements in ambulation and reductions in fatigue for individuals with MS.