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Published on: September 18, 2013
Prenylated flavonoids as tyrosinase inhibitors
Nan Kyoung Lee1, Kun Ho Son, Hyeun Wook Chang
1College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea.
Abstract:
In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable inhibitory activity. Especially, sanggenon D is revealed as a potent inhibitor (IC50 = 7.3 microM), compared to the reference compound, kojic acid (IC50 = 24.8 microM). However, the prenylation with isoprenyl group or the vinylation to flavonoid molecules did not enhance tyrosinase inhibitory activity.
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