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Published on: February 21, 2014
[Expression and correlation of C-met and estrogen receptor in endometrial carcinomas]
Yuedong He1, Zhilan Peng, Xiaoling Pan
1Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the expression and correlation of C-met and Estrogen receptor (ER) in endometrial carcinomas.
Methods:
We examined 55 samples of endometrial carcinomas using specific polyclonal endometrial carcinomas.
Methods:
antibody and monoclonal antibody correspondent to the human C-met and ER respectively. The histochemical score was estimated according to the formula H = (i + 1) x pi, with a criterion of equal or more than 70 as considered to be positive in expression.
Results:
The expression of C-met was correlated with both histological grade and clinical stage of endometrial carcinomas. The H scores of carcinomas in grade 3 was higher than in grade 1 and grade 2, while higher H scores were found in carcinomas in stage III and II compared to stage I (P < 0.05). The higher of the grade and stage were, the weaker the ER were expressed in endometrial carcinomas (P < 0.05). There was an inverse correlation between the expression of ER and C-met (r = -0.5842 P < 0.05).
Conclusions:
The expression of C-met and ER might be a useful predictor for the prognosis of endometrial carcinomas and an indicator to evaluate the effectiveness of the hormone intervention.
