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Related Experiment Videos

NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins.

Kim D Pruitt1, Tatiana Tatusova, Donna R Maglott

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 6An.12J, 45 Center Drive, Bethesda, MD 20892-6510, USA. pruitt@ncbi.nlm.nih.gov

Nucleic Acids Research
|December 21, 2004
PubMed
Summary

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NCBI RefSeq: reference sequence standards through 25 years of curation and annotation.

Nucleic acids research·2024

The NCBI RefSeq database offers a comprehensive, non-redundant collection of genomic, transcript, and protein sequences from over 2400 organisms. It links sequences to other resources and provides detailed annotations for scientific research.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • The NCBI Reference Sequence (RefSeq) database is a crucial resource for genomic data.
  • It aims to provide a complete sequence information dataset for all species.

Purpose of the Study:

  • To describe the scope and content of the NCBI RefSeq database.
  • To highlight its role in providing non-redundant sequence data and annotations.

Main Methods:

  • Data aggregation from archival databases.
  • Integration of nucleotide and protein sequences.
  • Annotation using community input, automated processes, and expert curation.

Main Results:

  • The database contains data from over 2400 organisms, including over one million proteins.

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  • It covers diverse taxonomic groups: prokaryotes, eukaryotes, and viruses.
  • Sequences are linked to NCBI Map Viewer, Gene, and other resources.

    • Conclusions:

    • RefSeq provides a valuable, curated, and linked resource for biological research.
    • Its comprehensive nature and detailed annotations support a wide range of scientific inquiries.